Dr. Meha Sharma is on the forefront among the new generation of rheumatologist from India, who believe in newer innovations in the practice of Rheumatology & Immunology with the aim of improving patient care, comfort and satisfaction. She has contributed several important original research papers in the field of rheumatoid arthritis, gout, osteoarthritis, lupus, vitamin-D metabolism and bone health. She is among the first to highlight the burden of poor bone health among young Indians with rheumatoid arthritis, and the need to take urgent interventions to prevent fractures in later life. Her work on pleotrophic benefits of hydroxychloroquine, and meta-analysis on several clinically relevant topics have been well recognised in the scientific community.

Research Publications

  1. Dutta D, Kadian J, Mahajan K, Dhall A, Sharma M. Efficacy and safety of luseogliflozin in improving glycaemic and non-glycaemic outcomes in type-2 diabetes: A meta-analysis. Diabetes Metab Syndr. 2023 Mar;17(3):102742. doi: 10.1016/j.dsx.2023.102742. Epub 2023 Mar 13. PMID: 36933330.
  2. Dutta D, Mohindra R, Kumar M, Kumar A, Sharma M. Ranirestat Improves Electrophysiologic but not Clinical Measures of Diabetic Polyneuropathy: A Meta-Analysis. Indian J Endocrinol Metab. 2022 Sep-Oct;26(5):399-406. doi: 10.4103/ijem.ijem_242_22. Epub 2022 Nov 22. PMID: 36618527; PMCID: PMC9815196
  3. Dutta D, Bhattacharya S, Kumar M, Datta PK, Mohindra R, Sharma M. Efficacy and safety of novel thiazolidinedione lobeglitazone for managing type-2 diabetes a meta-analysis. Diabetes Metab Syndr. 2023 Jan;17(1):102697. doi: 10.1016/j.dsx.2022.102697. Epub 2022 Dec 23. PMID: 36580702.
  4. Dutta D, Khandelwal D, Kumar M, Sharma M. Efficacy and safety of novel dual glucokinase activator dorzagliatin in type-2 diabetes A meta-analysis. Diabetes Metab Syndr. 2023 Jan;17(1):102695. doi: 10.1016/j.dsx.2022.102695. Epub 2022 Dec 20. PMID: 36566614.
  5. Dutta D, Surana V, Bhattacharya S, Aggarwal S, Sharma M. Efficacy and Safety of Novel Non-steroidal Mineralocorticoid Receptor Antagonist Finerenone in the Management of Diabetic Kidney Disease: A Meta-analysis. Indian J Endocrinol Metab. 2022 May-Jun;26(3):198-205. doi: 10.4103/ijem.ijem_376_21. Epub 2022 Apr 29. PMID: 36248038; PMCID: PMC9555385.
  6. Dutta D, Mohindra R, Mahajan K, Sharma M. Performance of Fast-Acting Aspart Insulin as Compared to Aspart Insulin in Insulin Pump for Managing Type 1 Diabetes Mellitus: A Meta-Analysis. Diabetes Metab J. 2023 Jan;47(1):72-81. doi: 10.4093/dmj.2022.0035. Epub 2022 Jun 24. PMID: 35746893; PMCID: PMC9925142.
  7. Dutta D, Kumar M, Shivaprasad KS, Kumar A, Sharma M. Impact of semaglutide on biochemical and radiologic measures of metabolic-dysfunction associated fatty liver disease across the spectrum of glycaemia: A meta-analysis. Diabetes Metab Syndr. 2022 Jun;16(6):102539. doi: 10.1016/j.dsx.2022.102539. Epub 2022 Jun 10. PMID: 35709586.
  8. Dutta D, Surana V, Singla R, Aggarwal S, Sharma M. Efficacy and safety of novel twincretin tirzepatide a dual GIP and GLP-1 receptor agonist in the management of type-2 diabetes: A Cochrane meta-analysis. Indian J Endocrinol Metab. 2021 Nov-Dec;25(6):475-489. doi: 10.4103/ijem.ijem_423_21. Epub 2022 Feb 17. PMID: 35355921; PMCID: PMC8959203.
  9. Dutta D, Mohindra R, Surana V, Sharma M. Safety and efficacy of once weekly dipeptidyl-peptidase-4 inhibitor trelagliptin in type-2 diabetes: A meta-analysis. Diabetes Metab Syndr. 2022 Apr;16(4):102469. doi: 10.1016/j.dsx.2022.102469. Epub 2022 Mar 21. PMID: 35344848.
  10. Dutta D, Sharma M, Aggarwal S, Agarwal A, Dhall A. Treatment outcomes of graded dose of empagliflozin in type-2 diabetes: A real world study. Ann Afr Med. 2022 Jan-Mar;21(1):26-33. doi: 10.4103/aam.aam_69_20. PMID: 35313401; PMCID: PMC9020632.
  11. Dutta D, Mahajan K, Kumar M, Sharma M. Efficacy and safety of long-acting growth hormone in adult growth hormone deficiency: A systematic review and meta-analysis. Diabetes Metab Syndr. 2022 Feb;16(2):102421. doi: 10.1016/j.dsx.2022.102421. Epub 2022 Feb 8. PMID: 35158212.
  12. Dutta D, Agarwal A, Maisnam I, Singla R, Khandelwal D, Sharma M. Efficacy and Safety of the Novel Dipeptidyl Peptidase-4 Inhibitor Gemigliptin in the Management of Type 2 Diabetes: A Meta-Analysis. Endocrinol Metab (Seoul). 2021 Apr 6. doi: 10.3803/EnM.2020.818. [PubMed] PMID: 33820392 [IMPACT FACTOR: 3.26]
  13. Dutta D, Singla R, Surana V, Sharma M. Efficacy and Safety of Letrozole in the Management of Constitutional Delay in Growth and Puberty: A Systematic Review and Meta-analysis. J Clin Res Pediatr Endocrinol. 2021 Sep 3. doi: 10.4274/jcrpe.galenos.2021.2021.0169. [PubMed] PMID: 34477355 [IMPACT FACTOR: 2.15]
  14. Dutta D, Jindal R, Kumar M, Mehta D, Dhall A, Sharma M. Efficacy and safety of once weekly thyroxine as compared to daily thyroxine in managing primary hypothyroidism: A systematic review and meta-analysis. Indian J Endocr Metab 2021;25:76-85 [PubMed] PMID: 34660234 [IMPACT FACTOR: 1.7]
  15. Dutta D, Jindal R, Mehta D, Khandelwal D, Sharma M. Efficacy and safety of novel sodium glucose cotransporter-2 inhibitor remogliflozin in the management of type 2 diabetes mellitus: A systematic review and meta-analysis. Diabetes Metab Syndr. 2021;15(6):102315. doi: 10.1016/j.dsx.2021.102315. [PubMed] PMID: 34700292
  16. Dutta D, Bhattacharya S, Surana V, Aggarwal S, Singla R, Khandelwal D, Sharma M. Efficacy and safety of saroglitazar in managing hypertriglyceridemia in type-2 diabetes: A meta-analysis. Diabetes Metab Syndr. 2020 Aug 31. doi.org/10.1016/j.dsx.2020.08.039 [PubMed] PMID: 32937280
  17. Dutta D, Bhattacharya S, Krishnamurthy A, Sharma LK, Sharma M. Efficacy and Safety of Novel Dipeptidyl-Peptidase-4 Inhibitor Evogliptin in the Management of Type 2 Diabetes Mellitus: A Meta-Analysis. Indian J Endocrinol Metab. 2020 Sep-Oct;24(5):434-445. [PubMed] PMID: 33489850 [IMPACT FACTOR: 1.7]
  18. Dutta D, Bhattacharya S, Sharma M, et al. Effect of yoga on glycemia and lipid parameters in type-2 diabetes: a meta-analysis. J Diabetes Metab Disord (2021). https://doi.org/10.1007/s40200-021-00751-0
  19. Dutta D, Sharma M, Sharma R. Short-term Hydroxychloroquine in COVID-19 Infection in People With or Without Metabolic Syndrome – Clearing Safety Issues and Good Clinical Practice. European Endocrinology. 2020;16(2):109–12 [PubMed] PMID: 33117441
  20. Dutta D, Bhattacharya S, Surana V, Aggarwal S, Singla R, Khandelwal D, Sharma M. Response to the letter to the editor submitted by Jaiswal A et al. (2020) regarding ‘efficacy and safety of saroglitazar in managing hypertriglyceridemia in type-2 diabetes: A meta-analysis’ (Dutta et al.), Diabetes Metab Syndr. 2020;14 (6): 2093 https://doi.org/10.1016/j.dsx.2020.10.027. [PubMed]
  21. Aggarwal A, Sharma M, Maisnam I, Ghosh S, Aggarwal S, Bhattacharya S, Dutta D. Drug-induced bone disorders: A systematic review. Indian J Rheumatol 2019;14:S44-51.
  22. Sharma M, Kumar M, Dutta D. Vitamin D Supplementation, Insulin Resistance, and Cardiovascular Risk Factors: Who are Likely to Benefit the Most? Indian J Endocrinol Metab. 2019 Nov-Dec;23(6):650-652. [PubMed] PMID: 32042706
  23. Dutta D, Sharma M, Aggarwal S, Mohindra R, Bhattacharya S, Kalra S. Vitamin D, Thyroid Autoimmunity and Cancer: An Interplay of Different Factors. Indian J Endocrinol Metab. 2019 Sep-Oct;23(5):507-513. [PubMed] PMID: 31803589
  24. Dutta D, Sharma M, Anand A, Garga UC, Bansal R, Sharma N. Increased trunk fat along with decreased peripheral fat as an important predictor of hypertriglyceridaemia & hypercholesterolaemia in Indians with HIV infection. Indian J Med Res. 2018 Oct;148(4):411-421 [PubMed] PMID: 30666003 [IMPACT FACTOR 1.4]
  25. Sharma M, Dhakad U, Wakhlu A, Bhadu D, Dutta D, Das SK. Lean Mass and Disease Activity are the Best Predictors of Bone Mineral Loss in the Premenopausal Women with Rheumatoid Arthritis. Indian J Endocrinol Metab. 2018 Mar-Apr;22(2):236-243. [PubMed] PMID: 29911038
  26. Dutta D, Gupta PK, Sharma M, Damble NA, Madan R, Dogra S.18F-Fluorocholine-Positron Emission Tomography/Computerised Tomography is Useful in Localising 99mTc-Sesta-methoxyisobutylisonitrile-Negative Parathyroid Cyst Causing Normocalcemic Primary Hyperparathyroidism. Eur Endocrinol. 2018 Apr;14(1):56-58. [PubMed] PMID: 29922354
  27. Bhadu D, Das SK, Wakhlu A, Dhakad U, Sharma M. Ultrasonographic detection of double contour sign and hyperechoic aggregates for diagnosis of gout: two sites examination is as good as six sites examination. Int J Rheum Dis. 2018 Feb;21(2):523-531. [PubMed] PMID: 29210196 [IMPACT FACTOR 1.98]
  28. Dutta D, Sharma M, Bansal R, Sharma N, Garga UC, Anand A, Gaurav K. Low skeletal mass is an important predictor of osteoporosis in HIV infected men in India. Endokrynol Pol. 2017 Oct 12. doi: 10.5603/EP.a2017.0053. PMID: 29022646 [PubMed] [IMPACT FACTOR 1.5]
  29. Mahajan K, Negi P, Merwaha R, Sharma M. Isolated tricuspid valve Libman-Sacks endocarditis in a patient with antiphospholipid antibody syndrome. BMJ Case Rep. 2017 Aug 22;2017. pii: bcr-2017-219217. doi: 10.1136/bcr-2017-219217. PMID: 28830895 [PubMed]
  30. Sharma M, Nolkha N, Sharma A, Bhadu D, Dhakad U, Singh R, Das SK. Spondyloarthropathy-Like Findings and Diffuse Osteosclerosis as the Presenting Feature of Pseudohypoparathyroidism. J Clin Rheumatol. 2016 Mar;22(2):102-4. PMID: 26906309 [PubMed] [IMPACT FACTOR 1.89]
  31. Dutta D, Sharma M, Mahajan V, Chopra P. Sclerosing angiomatoid nodular transformation of spleen masquerading as carcinoma breast metastasis: Importance of splenic biopsy in obviating splenectomy. Indian J Pathol Microbiol. 2016 Apr-Jun;59(2):223-226. PMID: 27166048 [PubMed] [IMPACT FACTOR: 0.466]
  32. Bhadu D, Kumar P, Malhotra KP, Sharma A, Sharma M, Srivastava D. Central nervous system vasculitis in pediatric microscopic polyangiitis: A case report and review of literature. Acta Reumatol Port. 2016 Feb 18. PMID: 27156236 [PubMed] [IMPACT FACTOR: 0.726]
  33. Bhadu D, Das SK, Dhakad U, Sharma M, Srivastava D, Tripathy SR. Synovial chondromatosis involving multiple joints in rheumatoid arthritis: A case report review of the literature. Int J Rheum Dis. 2016 Apr 29. [Epub ahead of print] PMID: 27126892 [PubMed] [IMPACT FACTOR: 1.98]
  34. Biswas K, Sharma M, Dutta D, Barman N. Ocular myasthenia with thyroid associated ophthalmopathy in subclinical Graves' disease: Diagnostic challenge and treatment outcomes. Thyroid Res Pract 2014;11:73-5.DOI: 10.4103/0973-0354.129734
  35. Dutta D, Biswas K, Sharma M, Maskey R, Baruah MP, Amin MF. Managing diabetes during Navratris with special focus on Durga pujas. J Soc Health Diabetes 2015;3:84-8 DOI: 10.4103/2321-0656.152804
  36. Nolkha N, Kumar P, Sharma A, Sharma M. Macrodactyly (Local gigantism). Indian Journal of Rheumatology. 2014; 9 (3) : 157 – 158 http://dx.doi.org/10.1016/j.injr.2014.06.003
  37. Sharma M. Study of cardiac valvular and annular calcification and its risk factors in chronic kidney disease stage 3-5 patients (Thesis for MD Medicine)

Presentations and Workshops (International):

  1. Presented research paper (Oral ePoster presentation) at the Annual conference of American Association of Clinical Endocrinologists (AACE), Nashville, TN, USA, May 13-17, 2015. [INCREASED SERUM FETUIN-A IS AN IMPORTANT ADVERSE PREDICTOR OF GLYCEMIC OUTCOMES IN PREDIABETES: A 4 YEAR PROSPECTIVE STUDY FROM INDIA]
  2. Presented 2 Original research papers at ENDO 2015 (Annual conference of the Endocrine Society, USA) at San Diego, CA, USA from March 5-8, 2015. [“Serum Free Vitamin-D Levels May be Better Predictors of Insulin Resistance in Individuals with Prediabetes” and “Selenoprotein-P Is Predictive of Insulin Resistance and Systemic Inflammation in Individuals with Prediabetes and Diabetes”]
  3. Participated in the Type 1 Diabetes Care and Management Fellows Conference conducted by the Endocrine Society USA at San Diego, CA, USA from March 2–3, 2015.
  4. Participated in 1st European Society of Pediatric Endocrinology (ESPE) Diabetes and Obesity Schoolat Tel Aviv, Jaffa, Israel from 23-26th April 2014.
  5. Presented Original research paper (oral presentation) at ICE/ENDO 2014 (International Congress of Endocrinology/ Endocrine Society) at Chicago, Illinois USA from June 21-24 2014.
  6. Presented poster at 49thEuropean Association for the Study of Diabetes (EASD) Annual Conference at Barcelona Spain, 23-27th September 2013. [Serum vitamin D may modulate fetuin-A,cytokines and insulin resistance across the spectrum of glycaemia. http://www.easdvirtualmeeting.org/resources/5920] Underwent training at the prestigious 20thYoung Scientist Training Course on advanced molecularmethods in diabetes conducted by EASD at Department of Biochemistry, Hanover Medical School,Hanover, Germany, from 21-25th October 2013
  7. Actively participated, underwent training at the Asia Pacific Pediatric Endocrine Society (APPES) Fellow School, Wuhan, China, 5th-11th Nov’13
  8. Member of Class of 2012, Endocrine Trainee Day, conducted by the Endocrine Society on 21st June2012 at George R Brown Convention Centre, Houston, Texas, USA
  9. Received Endocrine trainee Day scholarship from the Endocrine Society during the trainee day eventat George R Brown Convention Centre, Houston, Texas, USA
  10. Presented poster at ENDO-2012 (The Endocrine Society’s 94th Annual Meeting, Houston, Texas, USA from 22ndto 26thJune, 2012 [Relation of vitamin D status with insulin resistance and systemic inflammation in individuals withnormal glucose tolerance, prediabetes and diabetes: An eastern India perspective].

Presentations and Workshops (INDIA):

  1. Faculty and gave a presentation on Diabetic Gastroparesis at the National Mid-term Indian Society of Gastroenterology Meet (GASTROCON), Allahabad, 2nd and 3rd April 2016
  2. Senior faculty and speaker at East Delhi Physician Association Annual Conference (EDPACON) 2015. Presentation on “Management of Lipid Beyond statins and LDL; Indian perspective” on 13th December 2015
  3. Completed a Course on “Essentials of Statistics and Clinical Data Analysis using R Programming” at The International Centre for Genetic Engineering and Biotechnology (ICGEB) Campus, Aruna Asaf Ali Marg, New Delhi, 110067, from 1-4th December 2015, conducted by Clinical Development Services Agency, an extramural unit of THSTI, Department of Biotechnology, Ministry of Science & Technology, Government of India
  4. Senior faculty and speaker at 13th Annual Conference of Diabetic Foot Society of India (DFSICON) 2015, at PGIMER, Chandigarh from 20-22nd November 2015. Spoke on the importance of routine assessment of cardiovascular disease in patients with peripheral vascular disease on 20th November 2015.
  5. Senior faculty and speaker at Faculty at 25th Annual Conference of Indian Society of Hypertension (BP-CON 2015) held at ESIC Medical College, Faridabad, India from 20-22nd November 2015. Had a talk on metabolic modulations due to SGLT2 inhibitors on 21st November 2015.
  6. Senior Faculty at “Fundamentals in health research workshop” organized by Endocrine Society of India (ESI) 29-30 August 2015, New Delhi, India
  7. Successfully completed 14th Indian Council of Medical Research (ICMR) Course on Medical Genetics and Genetic Counseling 20thJuly-1st August 2015 at Sanjay Gandhi Post Graduate Institute of Medical Sciences (SGPGIMS), Lucknow, India
  8. Faculty at annual conference at Integrated Diabetes & Endocrinology Academy (IDEA-CON) 2015 . Had oral presentation on “Approach to thyroid nodules: An Endocrinologist’s perspective” on 20th June 2015
  9. Actively participated and successfully completed workshop, “Practical Research 2014” organized by the George Institute for Global Heath from 22-25th September 2014, New Delhi, India.
  10. Oral presentation on “Home management of diabetes” on World Kidney Day (12th March 2015) organized by Department of Nephrology at PGIMER & Dr. RML Hospital, New Delhi, India.

Skills & Achievemant

  1. Awarded the best research paper published in Indian Journal of Endocrinology and Metabolism for the year 2016 at the 46th Annual Scientific meeting of Endocrine Society of India Annual Conference (ESICON) 2016 at New Delhi (21-23rd October 2016).
  2. Awarded Gold Medal (Prof Shailendra K Vajpeyee Award) for best oral research paper presentation by the Indian Society of Hypertension at BP-CON 2015 (22nd Nov’ 15) for presenting the original work highlighting the importance of neck-height ratio as a very good predictor of metabolic syndrome among Asian Indians.
  3. Winner of AV Gandhi award for best Clinical research paper carrying prize of Rs 1,00,000 /- at International Clinical Update in Endocrinology, Hyderabad, 2nd Feb’14 1st Runner up of national level Endocrinology Quiz conducted by Endocrine Society of India (ESI) Torrent Young Scholar Award (TYSA) year 2012, at Ahmedabad with Prize of Rs 50,000
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